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Archived from the original on 13 April Retrieved 18 August Archived from the original on 14 October Retrieved 26 August Archived from the original on 9 July Retrieved 3 November Retrieved 19 December London Evening Standard. Daily News. New York. BBC Sports. FT Magazine. Retrieved 19 January Associated Press. Die Welt in German. Retrieved 8 May Retrieved 14 November Retrieved 13 September Retrieved 1 April Retrieved 27 March Retrieved 5 April Retrieved 2 May Toronto Star. Retrieved 17 May Retrieved 21 July Retrieved 18 July Augsburger Allgemeine.

Retrieved 8 August Retrieved 7 August Deutsche Welle. Retrieved 15 August Retrieved 21 October Retrieved 25 February Retrieved 11 March Retrieved 9 April Retrieved 16 April Retrieved 22 April Retrieved 9 May Retrieved 13 July Retrieved 18 December The Guardian in German. Retrieved 5 January Retrieved 4 May Retrieved 21 May Retrieved 23 April Retrieved 1 February Retrieved 20 July Retrieved 14 August Retrieved 18 September Retrieved 24 September Retrieved 11 October PA Sport.

Retrieved 15 January Retrieved 17 March Retrieved 14 September Manchester City F. Retrieved 5 August Retrieved 13 May Retrieved 24 April Retrieved 18 May Retrieved 4 August Retrieved 11 November FOX Sports Asia. Retrieved 27 December Retrieved 10 June Retrieved 30 October Barca Blaugranes. Retrieved 4 October The mere threat of it would allow City much more space to play their game — if the Blues' centre-backs come short and the pacy attackers run 20 yards beyond the halfway line, who do the opposition pick up, and how do they do it? Retrieved 2 December Retrieved 26 March Der Spiegel.

Retrieved 15 June Retrieved 29 May Sports Illustrated. Retrieved 24 July Retrieved 24 February La Vanguardia. Retrieved 22 July National Football Teams. Benjamin Strack-Zimmerman.

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Archived from the original on 1 March Retrieved 26 January World Football. Retrieved 19 February Retrieved 7 July Premier League. World Soccer. Retrieved 6 October France Football. Retrieved 20 March Retrieved 19 March Archived from the original on 29 November Collell, Jaume Riera, Josep Guardiola, Pep Paraula de Pep. Ara Llibres. Current Premier League managers. Fabien Barthez Francesco Toldo. Bravo Award. European Coach of the Year. Name required. Softball closes out season against Omaha Mavericks. Leathernecks baseball surprises Iowa with late comeback but come up short in loss.

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Softball comes up wth three-game sweep on Senior Day. Skip to content Free download. Book file PDF easily for everyone and every device. Modeling studies support that QIVs are expected to prevent more influenza cases, hospitalisations and deaths than TIVs, although estimates of the case numbers prevented vary according to local specificities.

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The value of QIVs is demonstrated by their capacity to broaden the immune response and reduce the likelihood of a B-mismatched season. The vast majority of human disease is caused by types A and B, which are genetically and structurally similar, but differ in biology, evolutionary and epidemiological framework. Influenza viruses undergo constant mutation which enables evasion of existing host immunity leading to recurrent infections that manifest as annual outbreaks.

The evaluation of influenza viruses and vaccine development. Influenza affects all age-groups and while most deaths occur in older adults, influenza deaths also occur in children.

The vaccine influenza A subtype was changed in and in in response to influenza A shifts that triggered severe pandemics Fig. We identified modeling studies estimating the potential impact of QIVs compared with TIVs in terms of clinical outcomes prevented. Addition of the fourth strain had no impact on the reactogenicity and safety profile of the vaccine.

In adults, Fluarix demonstrated statistically significant efficacy of The failure to meet this non-inferiority criterion may be related to a high baseline prevalence of seropositivity against this strain. At least Post-hoc analyses demonstrated superiority of the HI antibody response for the added B lineage. Influenza B causes epidemics approximately every 2—4 years 42,43 that impact all age-groups but proportionally more older children. A systematic review of the literature describing influenza B disease published between and concluded that influenza B was more likely to be severe in children than in adults.

For QIVs, modeling studies are sometimes used to assess cost-effectiveness and whether the added value of the vaccine is likely to offset the added cost; models may also contribute information about the societal value of QIVs quantifying the number of preventable influenza outcomes compared with TIVs.

The reported added value of QIVs comes from its capacity to provide broader immunity against influenza B, thereby reducing the likelihood of a mismatched season. We systematically queried the PubMed database for papers reporting the potential value of QIVs compared with TIVs in terms of illness, hospitalisations and deaths averted using the search string provided in Fig. Articles were selected by a 3-step selection procedure based on 1 screening of title and abstract, 2 screening of full-text article, and 3 final screening during the data-extraction phase.

The titles and abstracts retrieved from the Pubmed database were screened in duplicate by 2 independent researchers. The results were compared and discussed; all selected references from the 2 researchers were included for full text selection. Results of the literature search 30 October In case of discrepancy or disagreements during the selection, a third researcher was consulted and the study was discussed until consensus was reached. If articles reported on the same study, the most relevant or most complete article was included in this review.

If articles complemented each other, both articles were included.

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The reasons for exclusion of full-text papers were recorded. All of the estimates were highly dependent upon the choice of baseline data, such as the assumed degree of cross-protection afforded by TIVs and the level of mismatch in a given season. In all cases, the results of more conservative static models i. A summary of current disease burden information and the potential impact of QIVs on the influenza burden from modeling studies is presented for selected countries below. Summary of QIV modeling data in different countries: results from a review of the literature.

A prospective study of medically-attended visits for influenza-like-illness ILI in the US from — identified influenza B in The preventable burden each year ranged from 2,—, illnesses, 14—8, hospitalisations and 1— deaths. The all-age estimate obtained by another static model appeared similar, suggesting that QIVs would prevent 30, more influenza cases annually than TIVs.

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  5. Using data from a study that compared the difference between vaccination with QIVs vs. These studies illustrate that although the impact of QIVs may vary in any influenza season, the multi-year cumulative benefit of QIVs over TIVs are predicted to result in substantial societal benefit.